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Background
Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a ‘capping’ or ‘branching’ protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (PubMed: 15731013, PubMed: 18931701). Is a negative regulator of ciliogenesis (PubMed: 25270598).
Product overview
Product Name
Trichoplein Keratin Filament-Binding Protein
Code
E6318Hu
Assay type
Sandwich
Size
96 test
Sensitivity
7.45ng/L
Reactivity
Human
Detection range
7.45ng/L
Sample type
Serum, plasma, cell culture supernates
Synonyms
Mitochondrial protein with oncostatic activity;Mitostatin;Protein TCHP;TCHP;Trichoplein keratin filament-binding protein;Tumor suppressor protein
