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Human Thyroxine 5-Deiodinase, DIO3 ELISA Kit

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BT LAB continuously updates its ELISA Kit catalog with the latest, validated products. If you’re unable to download a datasheet, please contact us to request the most recent version.

Background

Responsible for the deiodination of T4 (3,5,3′,5′-tetraiodothyronine) into RT3 (3,3′,5′-triiodothyronine) and of T3 (3,5,3′-triiodothyronine) into T2 (3,3′-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development.

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