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Background
Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix.
Product overview
Product Name
Terf1 Interacting Nuclear Factor 2
Code
E6467Hu
Assay type
Sandwich
Size
96 test
Sensitivity
0.027ng/ml
Reactivity
Human
Detection range
0.027ng/ml
Sample type
Serum, plasma, cell culture supernates
Synonyms
TERF1-interacting nuclear factor 2;TINF 2;TINF2;TRF1-interacting nuclear protein 2
