Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion Channels, membrane transporters, cell growth, survival and proliferation. Up-regulates Na(+) Channels: SCNN1A/ENAC, K(+) Channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase.
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