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Background
Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter (By similarity).
Product overview
Product Name
Rho Gtpase-Activating Protein 22
Code
E6091Hu
Assay type
Sandwich
Size
96 test
Sensitivity
4.91ng/L
Reactivity
Human
Detection range
4.91ng/L
Sample type
Serum, plasma, cell culture supernates
Synonyms
ARHGAP 22;ARHGAP22;Rho GTPase-activating protein 22;Rho-type GTPase-activating protein 22
