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Background
Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.
Product overview
Product Name
Protein Phosphatase 2A
Code
E6870Hu
Assay type
Sandwich
Size
96 test
Sensitivity
0.018ng/ml
Reactivity
Human
Detection range
0.018ng/ml
Sample type
Serum, plasma, cell culture supernates
Synonyms
PP2C-alpha;PPM 1A;PPM1A;Protein phosphatase 1A;Protein phosphatase 2C isoform alpha;Protein phosphatase IA
