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Background
Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation. Isoform Gamma is a site-specific single-strand endoribonuclease that cleaves single strand RNA 3′ to purines and pyrimidines in A+U-rich regions. It generates 5′-phosphate termini at the site of cleavage. This isoform does not inhibit PP-1. May be implicated in mRNA splicing.
Product overview
Product Name
Nuclear Inhibitor of Protein Phosphatase 1
Code
E5794Hu
Assay type
Sandwich
Size
96 test
Sensitivity
9.19ng/L
Reactivity
Human
Detection range
9.19ng/L
Sample type
Serum, plasma, cell culture supernates
Synonyms
ARD-1;NIPP-1;Nuclear inhibitor of protein phosphatase 1;PPP 1R8;PPP1R8;Protein phosphatase 1 regulatory inhibitor subunit 8 [Includes: Activator of RNA decay