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Background
Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions.
Product overview
Product Name
Mothers Against Decapentaplegic Homolog 6
Code
E4442Hu
Assay type
Sandwich
Size
96 test
Sensitivity
4.72ng/L
Reactivity
Human
Detection range
4.72ng/L
Sample type
Serum, plasma, cell culture supernates
Synonyms
hSMAD6;MAD homolog 6;Mothers against decapentaplegic homolog 6;Mothers against DPP homolog 6;SMAD 6;SMAD family member 6;Smad6
