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Background
Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed: 20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed: 22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed: 28873464).
Product overview
Product Name
Integrin beta4
Code
E3031Hu
Assay type
Sandwich
Size
96 test
Sensitivity
0.23ng/ml
Reactivity
Human
Detection range
0.23ng/ml
Sample type
Serum, plasma, cell culture supernates
Synonyms
CD antigen CD104;GP150;Integrin beta-4;ITGB 4;ITGB4
