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Background
Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.
Product overview
Product Name
Heat shock protein 75 kDa, mitochondrial
Code
E5375Hu
Assay type
Sandwich
Size
96 test
Sensitivity
0.14ng/mL
Reactivity
Human
Detection range
0.14ng/mL
Sample type
Serum, plasma, cell culture supernates
Synonyms
Heat shock protein 75 kDa, mitochondrial;HSP 75;HSP75;HSP90L;TNFR-associated protein 1;TRAP1;TRAP-1;Tumor necrosis factor type 1 receptor-associated protein