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Background
Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR) (PubMed: 28575658). Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange (PubMed: 26681308). Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3. Also involved in interstrand cross-link repair (PubMed: 26253028).
Product overview
Product Name
Dna Repair Protein Rad51 Homolog 1
Code
E1370Hu
Assay type
Sandwich
Size
96 test
Sensitivity
0.11ng/ml
Reactivity
Human
Detection range
0.11ng/ml
Sample type
Serum, plasma, cell culture supernates
Synonyms
DNA repair protein RAD51 homolog 1;hRAD51;HsRAD51;RAD51;RAD51 homolog A
