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Background
Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton Channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc.
Product overview
Product Name
Cytochrome B-245 Heavy Chian
Code
E3974Hu
Assay type
Sandwich
Size
96 test
Sensitivity
5.13ng/L
Reactivity
Human
Detection range
5.13ng/L
Sample type
Serum, plasma, cell culture supernates
Synonyms
CGD91-phox;CYBB;Cytochrome b(558 subunit beta;Cytochrome b-245 heavy chain;Cytochrome b558 subunit beta;gp91-1;gp91-phox;Heme-binding membrane glycoprotein gp91phox;NADPH oxidase 2;Neutrophil cytochrome b 91 kDa polypeptide;p22 phagocyte B-cytochrome;Superoxide-generating NADPH oxidase heavy chain subunit