Home / Elisa Kits / BT LAB / Human Atp-binding Cassette Sub-family A Member 2, ABCA2 ELISA Kit

Human Atp-binding Cassette Sub-family A Member 2, ABCA2 ELISA Kit

Product Summary

Ordering Information

BT LAB continuously updates its ELISA Kit catalog with the latest, validated products. If you’re unable to download a datasheet, please contact us to request the most recent version.

Background

Probable lipid tranporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (PubMed: 15238223, PubMed: 21810484, PubMed: 24201375) (Probable). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes (PubMed: 24201375). In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP (PubMed: 22086926, PubMed: 26510981). May play a role in myelin formation (By similarity).

Product overview

Related Resources

Quotation request