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Background
Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site.
Product overview
Product Name
Aryl Hydrocarbon Receptor Repressor
Code
E2832Hu
Assay type
Sandwich
Size
96 test
Sensitivity
5.35ng/L
Reactivity
Human
Detection range
5.35ng/L
Sample type
Serum, plasma, cell culture supernates
Synonyms
AhR repressor;AHRR;Aryl hydrocarbon receptor repressor;bHLHe77;Class E basic helix-loop-helix protein 77
