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Background
Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.
Product overview
Product Name
Neuroendocrine protein 7B2
Code
E5755Hu
Assay type
Sandwich
Size
96 test
Sensitivity
0.027ng/mL
Reactivity
Human
Detection range
0.027ng/mL
Sample type
Serum, plasma, cell culture supernates
Synonyms
7B2;C-terminal Peptide];Neuroendocrine protein 7B2;N-terminal Peptide;P7B2;Pituitary polypeptide;SCG5;Secretogranin V;Secretogranin-5;Secretory granule endocrine protein I;SGNE1;SgV
