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Background
Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors (PubMed:14966521, PubMed:15694321).
Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (PubMed:15895088).
Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity).
Product overview
Product Name
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
Code
E5563Hu
Assay type
Sandwich
Size
96 test
Sensitivity
0.056ng/mL
Reactivity
Human
Detection range
0.056ng/mL
Sample type
Serum, plasma, cell culture supernates
Synonyms
LERN1;Leucine-rich repeat and immunoglobulin domain-containing protein 1;Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1;Leucine-rich repeat neuronal protein 1;Leucine-rich repeat neuronal protein 6A;LINGO1;LRRN6A;MRT64;UNQ201;
