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Background
Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (PubMed: 29993042). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (PubMed: 29993042).
Product overview
Product Name
C-C Motif Chemokine 2
Code
E1707Mo
Assay type
Sandwich
Size
96 test
Sensitivity
0.93pg/ml
Reactivity
Mouse
Detection range
0.93pg/ml
Sample type
Serum, plasma, cell culture supernates
Synonyms
C-C motif chemokine 2;CCL 2;CCL2;MCP-1;Monocyte chemoattractant protein 1;Monocyte chemotactic protein 1;Platelet-derived growth factor-inducible protein JE;Small-inducible cytokine A2
