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Background
Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3′-untranslated regions (3′-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor. Promotes assembly of stress granules (SGs), when overexpressed (By similarity).
Product overview
Product Name
Cold-inducible RNA-binding protein
Code
E1332Ra
Assay type
Sandwich
Size
96 test
Sensitivity
2.47ng/L
Reactivity
Rat
Detection range
2.47ng/L
Sample type
Serum, plasma, cell culture supernates
Synonyms
A18 hnRNP;CIRBP;Cold-inducible RNA-binding protein;Glycine-rich RNA-binding protein CIRP
