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Background
Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.
Product overview
Product Name
Osteoprotegerin
Code
E0110Mo
Assay type
Sandwich
Size
96 test
Sensitivity
5.45ng/L
Reactivity
Mouse
Detection range
5.45ng/L
Sample type
Serum, plasma, cell culture supernates
Synonyms
Osteoclastogenesis inhibitory factor;Osteoprotegerin;TNFRSF 11B;TNFRSF11B;Tumor necrosis factor receptor superfamily member 11B
