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Background
Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.
Product overview
Product Name
NACHT,LRR and PYD domains-containing protein 2
Code
E4050hu
Assay type
Sandwich
Size
96 test
Sensitivity
5.12ng/L
Reactivity
Human
Detection range
5.12ng/L
Sample type
Serum, plasma, cell culture supernates
Synonyms
CLR19.9;NACHT, LRR and PYD domains-containing protein 2;NALP2;NBS1;NLRP2;Nucleotide-binding site protein 1;PAN1;PYPAF2;PYRIN domain and NACHT domain-containing protein 1;PYRIN-containing APAF1-like protein 2
