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Background
Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase (PubMed:10358004).
Binds tRNA. Possesses inflammatory cytokine activity (PubMed:11306575).
Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation (By similarity).
Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels (By similarity).
Promotes dermal fibroblast proliferation and wound repair (PubMed:16472771).
Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum (By similarity).
Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations (PubMed:12237313).
Induces maturation of dendritic cells and monocyte cell adhesion (PubMed:11818442).
Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7 (PubMed:19362550).
Product overview
Product Name
Aminoacyl tRNA Synthase complex-interacting multifunctional protein 1
Code
E4939Hu
Assay type
Sandwich
Size
96 test
Sensitivity
7.39ng/L
Reactivity
Human
Detection range
7.39ng/L
Sample type
Serum, plasma, cell culture supernates
Synonyms
Aminoacyl tRNA Synthase complex-interacting multifunctional protein 1;EMAP2;EMAP-2;EMAPII;EMAP-II;Endothelial monocyte-activating polypeptide 2;Endothelial monocyte-activating polypeptide II;HLD3;Multisynthase complex auxiliary component p43;p43;SCYE1;Small inducible cytokine subfamily E member 1]
