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Background
Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A-ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4.
Product overview
Product Name
Bone Morphogenetic Protein 2
Code
E0276Ra
Assay type
Sandwich
Size
96 test
Sensitivity
2.51ng/L
Reactivity
Rat
Detection range
2.51ng/L
Sample type
Serum, plasma, cell culture supernates
Synonyms
BMP 2;BMP2;BMP-2;BMP-2A;Bone morphogenetic protein 2;Bone morphogenetic protein 2A
