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Background
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed: 18524778). Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (PubMed: 26206087). Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning (PubMed: 18505822).
Product overview
Product Name
Dickkopf-Related Protein 1
Code
E2006Mo
Assay type
Sandwich
Size
96 test
Sensitivity
14.12ng/L
Reactivity
Mouse
Detection range
14.12ng/L
Sample type
Serum, plasma, cell culture supernates
Synonyms
Dickkopf-1;Dickkopf-related protein 1;DKK 1;DKK1;Dkk-1;mDkk-1
