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Background
Binds to zinc finger protein TNFAIP3 and inhibits NF-kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13-acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding.
Product overview
Product Name
TNFAIP3-interacting protein 3
Code
E6280Hu
Assay type
Sandwich
Size
96 test
Sensitivity
7.06ng/L
Reactivity
Human
Detection range
7.06ng/L
Sample type
Serum, plasma, cell culture supernates
Synonyms
A20-binding inhibitor of NF-kappa-B activation 3;ABIN-3;LIND;Listeria-induced gene protein;TNFAIP3-interacting protein 3;TNIP3
