Prolow-density lipoprotein receptor-related protein 1 (LRP1) is an endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. LRP1 is widely expressed on many cell types including neurons, adipocytes, hepatocytes, vascular smooth muscle cells, fibroblasts, keratinocytes, macrophages, and megakaryocytes. Human LRP1 is an N-glycosylated and sialylated molecule that is cleaved in the Golgi apparatus to produce an 85 kDa transmembrane beta chain and a 515 kDa alpha chain that associates noncovalently with the beta chain but does not itself cross the membrane.
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