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Background
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6.
Product overview
Product Name
Bone Morphogenetic Protein Receptor 2
Code
E1563Hu
Assay type
Sandwich
Size
96 test
Sensitivity
1.64ng/L
Reactivity
Human
Detection range
1.64ng/L
Sample type
Serum, plasma, cell culture supernates
Synonyms
BMP type II receptor;BMP type-2 receptor;BMPR 2;BMPR2;BMPR-2;BMPR-II;Bone morphogenetic protein receptor type II;Bone morphogenetic protein receptor type-2