Apolipoprotein E is a glycoprotein synthesized mainly in the liver and the brain and is a component of most lipoproteins with the exception of low-density lipoproteins (LDL). Apolipoprotein E mediates the binding, internalization, and catabolism of lipoprotein particles. Additionally, it can serve as a ligand for the LDL (Apolipoprotein B/E) receptor and for the specific Apolipoprotein E receptor (chylomicron remnant) of hepatic tissues.
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