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Background
Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis (PubMed:2991281, PubMed:21357570, PubMed:6995544).
HMGCR is the main target of statins, a class of cholesterol-lowering drugs (PubMed:11349148, PubMed:18540668).
Product overview
Product Name
3-hydroxy-3-methylglutaryl-Coenzyme A Synthase 1
Code
E0957Hu
Assay type
Sandwich
Size
96 test
Sensitivity
0.094ng/mL
Reactivity
Human
Detection range
0.094ng/mL
Sample type
Serum, plasma, cell culture supernates
Synonyms
3-hydroxy-3-methylglutaryl-coenzyme A reductase;HMG-CoA reductase;HMGCS1;LDLCQ3
