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Background
Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3′-untranslated regions (3′-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed.
Product overview
Product Name
Cold Inducible Rna Binding Protein
Code
E7183Hu
Assay type
Sandwich
Size
96 test
Sensitivity
7.98ng/L
Reactivity
Human
Detection range
7.98ng/L
Sample type
Serum, plasma, cell culture supernates
Synonyms
A18 hnRNP;CIRBP;Cold-inducible RNA-binding protein;Glycine-rich RNA-binding protein CIRP
