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Background
Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Product overview
Product Name
Mothers Against Decapentaplegic Homolog 7
Code
E0078Ra
Assay type
Sandwich
Size
96 test
Sensitivity
0.025ng/ml
Reactivity
Rat
Detection range
0.025ng/ml
Sample type
Serum, plasma, cell culture supernates
Synonyms
MAD homolog 7;Mothers against decapentaplegic homolog 7;Mothers against DPP homolog 7;SMAD 7;SMAD family member 7;Smad7
