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Background
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). Has been shown to be also activated by TGF-beta (transforming growth factor) type I receptor kinase in rat intestinal epithelial cells (IEC 4-1). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (By similarity).
Product overview
Product Name
Mothers against decapentaplegic homolog 1
Code
E0077Ra
Assay type
Sandwich
Size
96 test
Sensitivity
4.1ng/L
Reactivity
Rat
Detection range
4.1ng/L
Sample type
Serum, plasma, cell culture supernates
Synonyms
MAD homolog 1;Madh1;Mothers against decapentaplegic homolog 1;Mothers against DPP homolog 1;SMAD 1;SMAD family member 1;Smad1
