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Background
Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:15923619, PubMed:28803732).
Required for normal fusion of the chorion and the allantois during placenta development (PubMed:11543617).
Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed:28803732).