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Background
Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. [Isoform 2]: Does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.
Product overview
Product Name
Growth Factor Receptor-Bound Protein 2
Code
E2656Mo
Assay type
Sandwich
Size
96 test
Sensitivity
11.66ng/L
Reactivity
Mouse
Detection range
11.66ng/L
Sample type
Serum, plasma, cell culture supernates
Synonyms
Adapter protein GRB2;GRB 2;GRB2;Growth factor receptor-bound protein 2;SH2/SH3 adapter GRB2
