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Background
Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
Product overview
Product Name
Tumor Necrosis Factor Receptor Superfamily Member 1B
Code
E6846Hu
Assay type
Sandwich
Size
96 test
Sensitivity
10.98ng/L
Reactivity
Human
Detection range
10.98ng/L
Sample type
Serum, plasma, cell culture supernates
Synonyms
CD antigen CD120b;Etanercept;p75;p80 TNF-alpha receptor;TBP-2;TBPII;TNF-R2;TNFR-II;TNF-RII;TNFRSF 1B;TNFRSF1B;Tumor necrosis factor receptor 2;Tumor necrosis factor receptor superfamily member 1B;Tumor necrosis factor receptor superfamily member 1b, membrane form;Tumor necrosis factor receptor type II;Tumor necrosis factor-binding protein 2
