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Background
Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3′ and 5′ strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies.
Product overview
Product Name
Ribonuclease 3
Code
E2404Hu
Assay type
Sandwich
Size
96 test
Sensitivity
0.023ng/ml
Reactivity
Human
Detection range
0.023ng/ml
Sample type
Serum, plasma, cell culture supernates
Synonyms
DROSHA;p241;Protein Drosha;Ribonuclease 3;Ribonuclease III;RNase III
