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Background
RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript ‘caging’ into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Binds to the 3′-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Binds to the 5′-UTR of the Insulin-like growth factor 2 (IGF2) mRNAs.
Product overview
Product Name
Insulin-like Growth Factor 2 Mrna-Binding Protein 3
Code
E5474Hu
Assay type
Sandwich
Size
96 test
Sensitivity
9.87ng/L
Reactivity
Human
Detection range
9.87ng/L
Sample type
Serum, plasma, cell culture supernates
Synonyms
hKOC;IGF2 mRNA-binding protein 3;IGF2BP3;IGF-II mRNA-binding protein 3;IMP-3;Insulin-like growth factor 2 mRNA-binding protein 3;KH domain-containing protein overexpressed in cancer;VICKZ family member 3
