Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at ‘Lys-14’ (H3K14ac), and have reduced activity toward histone H4 (PubMed: 16387653). Through chromatin acetylation it may function in DNA replication (PubMed: 16387653). May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation (PubMed: 15251430, PubMed: 15528276). Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA (PubMed: 15029197). May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC (PubMed: 15029197). Represses hypoxia inducible factor’s (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1) (PubMed: 15897452). Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (By similarity).
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