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Background
Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage.
Product overview
Product Name
Cartilage Intermediate Layer Protein 1
Code
E6610Hu
Assay type
Sandwich
Size
96 test
Sensitivity
26.34ng/L
Reactivity
Human
Detection range
26.34ng/L
Sample type
Serum, plasma, cell culture supernates
Synonyms
Cartilage intermediate layer protein 1;Cartilage intermediate layer protein 1 C1;Cartilage intermediate layer protein 1 C2;Cartilage intermediate-layer protein;CILP;CILP-1
