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Background
Small-conductance calcium-activated nonselective cation (SCAN) Channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Can generate outwardly rectifying chloride Channel currents in airway epithelial cells and Jurkat T lymphocytes.
Product overview
Product Name
Anoctamin 6
Code
E2376Hu
Assay type
Sandwich
Size
96 test
Sensitivity
9.68ng/L
Reactivity
Human
Detection range
9.68ng/L
Sample type
Serum, plasma, cell culture supernates
Synonyms
ANO 6;ANO6;Anoctamin-6;SCAN Channel;Small-conductance calcium-activated nonselective cation Channel;Transmembrane protein 16F
