Bcl-2 is the founding member of the apoptotic-regulating Bcl-2 family of proteins. It is considered an apoptosis suppressor in many cell systems and has been shown to interact with many other proteins involved in cell cycle regulation, autophagy, mitochondrial membrane stability, and oxidative stress response, among many others. As such an important protein involved in cell regulation, mutation or damage to the protein’s structure or function are critically linked to a variety of cancers.
Rat Apoptosis regulator BAX, BAX ELISA Kit, E0034Ra
Bax is a pro-apoptotic factor of Bcl-2 family. It accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, Bax undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis.
Rat Amyloid beta peptide 1-42, Aβ1-42 ELISA Kit, E0093Ra
Amyloid Beta (Aβ) peptides are derived from amyloid precursor proteins (APP) through sequential proteolytic cleavage of APP by β-secretases and γ-secretases generating diverse Aβ species. Aβ can aggregate to form soluble oligomeric species and insoluble fibrillar or amorphous assemblies. Some forms of the aggregated peptides are toxic to neurons. Alzheimer’s disease is characterized by the accumulation of aggregated Aβ peptides in senile plaques and vascular deposits.
Human Asprosin, ASPROSIN ELISA Kit, E4095Hu
Asprosin is a hormone that targets the liver to increase plasma glucose levels. Asprosin is secreted by white adipose tissue and circulates in the plasma. Asprosin acts in response to fasting and promotes blood glucose elevation by binding to the surface of hepatocytes. It promotes hepatocyte glucose release by activating the protein kinase A activity in the liver, resulting in rapid glucose release into the circulation. Asprosin and Fibrillin-1 are encoded by single FBN1 gene, they are translated and secreted as single precursor protein. Upon secretion these two proteins are separated by furin.
Human arginine, Arg ELISA Kit, E1911Hu
A bitter tasting amino acid found in proteins and necessary for nutrition; its absence from the diet leads to a reduced production of spermatozoa.
Human Apolipoprotein E, Apo-E ELISA Kit, E1451Hu
Apolipoprotein E is a glycoprotein synthesized mainly in the liver and the brain and is a component of most lipoproteins with the exception of low-density lipoproteins (LDL). Apolipoprotein E mediates the binding, internalization, and catabolism of lipoprotein particles. Additionally, it can serve as a ligand for the LDL (Apolipoprotein B/E) receptor and for the specific Apolipoprotein E receptor (chylomicron remnant) of hepatic tissues.
Human Phosphorylated adenosine monophosphate activated protein kinase, AMPK ELISA Kit, E0746Hu
Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5′-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit.
Bovine Anti Mullerian Hormone, AMH ELISA Kit, E0241Bo
Anti mullerian hormone (AMH) is a member of the TGF beta superfamily. It is secreted as a homodimeric 140kD disulphide linked precursor that is cleaved to release the mature 30kD homodimer. Originally classified as a foetal testicular hormone that inhibits Mullerian duct development, AMH is expressed post natally by immature Sertoli cells, and to a lesser degree by granulosa cells. AMH plays a role in testicular differentiation and in the regulation of ovarian follicle growth.
Human Allopregnanolone, ALLO ELISA Kit, E7379Hu
Allopregnanolone is a GABAA receptor positive allosteric modulator. Neuroactive steroid.
Human Asymmetrical dimethylarginine, ADMA ELISA Kit, E1887Hu
Asymmetrical dimethylarginine (ADMA) is the most potentof them and represents a novel risk factor for endothelialdysfunction.