Fas Ligand (FasL), also known as Tumor necrosis factor ligand superfamily member 6 or CD95 ligand is a cytokine that binds to TNFRSF6/FAS/CD95, a receptor that transduces the apoptotic signal into cells. Fas Ligand is involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. It also initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Rat Fas Ligand has 93% amino acids sequence identity with mouse Fas Ligand.
Human Estrogen receptor Alpha, ESR1 ELISA Kit, E7871Hu
Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Can activate the transcriptional activity of TFF1.
Rat Endothelial nitric oxide synthase, eNOS ELISA Kit, E0465Ra
eNOS, or NOS3, is an endothelial enzyme which produces nitric oxide and is the constitutively activated form found primarily in the vasculature. The nitric oxide produced by this enzyme regulates vascular tone and platelet aggregation.
Rabbit Epidermal Growth Factor, EGF ELISA Kit, E0023Rb
EGF precursor is a large 1185 amino acid group 1 member of the EGF family growth factors. All EGF family growth factors are synthesized as transmembrane proteins that undergo proteolytic processing to generate soluble forms. Human EGF is a 53 amino acid long fragment of the extracellular domain of EGF precursor. As other group 1 members, EGF binds to, and activates the EGF receptor. This promotes EGFR dimerization. EGF has variety of diverse physiological effects. EGF activity is complicated by the fact that other EGF family members utilize EGF receptor. EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. EGF is proposed to affect growth and/or differentiation of many other fetal and adult tissues.
Goat Estrone Sulfate, E1S ELISA Kit, E0110GO
Estrone sulfate could be an important stimulant of tumorgrowth in hormone-dependent breast carcinoma.
Human Deoxypyridinoline, DPD ELISA Kit, E1455Hu
Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.
Human Dickkopf-3, DKK3 ELISA Kit, E2065Hu
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Human DEP domain-containing mTOR-interacting protein, DEPTOR ELISA Kit, E6973HU
DEPTOR is capable of inhibiting mTORC1 signaling and activation of mTORC2 signaling.
Rat Vitamin D-binding protein, DBP ELISA Kit, E0616Ra
Vitamin D Binding Protein, also known as gc-globulin, is a 458 – amino acid, glycosylated protein encoded by the gene GC, which is in the albumin gene family. The primary function of this protein is to bind Vitamin D and its metabolites and to transport them to tissue. Vitamin D Binding protein is highly expressed and secreted into serum primarily from hepatic cells. There are three common alleles of the protein (Gc1f, Gc1s, and Gc2), and several minor polymorphisms. Different glycosylation sites are found on the isoforms of Vitamin D binding protein, a selectively deglycosylated form produced by B cell ß-galactosidase and T cell sialidase is known as Macrophage Activating Factor. MAF has been found to block angiogenic effects of several proteins on vascular endothelial cells.
Rat Dopamine D2 receptor, D2R ELISA Kit, E0221Ra
This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.