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Background
Processively dephosphorylates ‘Ser-2’ and ‘Ser-5’ of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation.
Product overview
Product Name
RNA polymerase II subunit A C-terminal domain phosphatase
Code
E6507Hu
Assay type
Sandwich
Size
96 test
Sensitivity
9.32ng/L
Reactivity
Human
Detection range
9.32ng/L
Sample type
Serum, plasma, cell culture supernates
Synonyms
CCFDN;CTDP1;FCP1;RNA polymerase II subunit A C-terminal domain phosphatase;TFIIF-associating CTD phosphatase
