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Background
Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.
Product overview
Product Name
NEDD8
Code
E5744Hu
Assay type
Sandwich
Size
96 test
Sensitivity
9.87ng/L
Reactivity
Human
Detection range
9.87ng/L
Sample type
Serum, plasma, cell culture supernates
Synonyms
NEDD8;NEDD-8;Neddylin;Neural precursor cell expressed developmentally down-regulated protein 8;Ubiquitin-like protein Nedd8
