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Background
Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types (By similarity).
Plays a role in ciliogenesis.
Product overview
Product Name
Arf-GAP with SH3 Domain,ANK repeat and PH Domain-Coutaining Protein 1
Code
E4128hu
Assay type
Sandwich
Size
96 test
Sensitivity
9.91ng/L
Reactivity
Human
Detection range
9.91ng/L
Sample type
Serum, plasma, cell culture supernates
Synonyms
130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein;ADP-ribosylation factor-directed GTPase-activating protein 1;AMAP1;ARF GTPase-activating protein 1;Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1;ASAP1;CENTB4;DDEF1;DEF-1;Development and differentiation-enhancing factor 1;Differentiation-enhancing factor 1;PAG2;PAP;PIP2-dependent ARF1 GAP;ZG14P
