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Background
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination (PubMed:15350543).
Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity).
Product overview
Product Name
Neurogenic locus notch homolog protein 3
Code
E3263Hu
Assay type
Sandwich
Size
96 test
Sensitivity
36.17ng/L
Reactivity
Human
Detection range
36.17ng/L
Sample type
Serum, plasma, cell culture supernates
Synonyms
CADASIL;CADASIL1;CASIL;IMF2;LMNS;Neurogenic locus notch homolog protein 3;Notch 3;Notch 3 extracellular truncation;Notch 3 intracellular domain];NOTCH3
