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Background
Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation.
Product overview
Product Name
Receptor tyrosine-protein kinase erbB-3
Code
E2418Mo
Assay type
Sandwich
Size
96 test
Sensitivity
0.054ng/mL
Reactivity
Mouse
Detection range
0.054ng/mL
Sample type
Serum, plasma, cell culture supernates
Synonyms
C76256;Erbb;Erbb-;ERBB3;Erbb-3;Glial growth factor receptor;HER;Her3;Proto-oncogene-like protein c-ErbB-3;Receptor tyrosine-protein kinase erbB-3
