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Background
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner.
Lacks ligand binding affinity and suppresses ESR1/ER-alpha and ESR2 isoform 1/ER-beta1 mediated transcriptional activation and may act as a dominant negative regulator of estrogen action.
Unable to bind DNA and activate transcription due to the truncation of the DNA binding domain.
Unable to bind DNA and activate transcription due to the truncation of the DNA binding domain.
Product overview
Product Name
Estrogen Receptor beta
Code
E1121Ra
Assay type
Sandwich
Size
96 test
Sensitivity
7.22ng/L
Reactivity
Rat
Detection range
7.22ng/L
Sample type
Serum, plasma, cell culture supernates
Synonyms
Erb2;ERbeta;ER-beta;Estrogen receptor beta;Nuclear receptor subfamily 3 group A member 2
