Hormone that acts as a ligand for natriuretic Peptide receptor NPR3/NPR-C and promotes bone growth and physical endurance in muscle. Acts as a regulator of osteoblast differentiation and bone growth by binding to natriuretic Peptide receptor NPR3/NPR-C, thereby preventing binding between NPR3/NPR-C and natriuretic Peptides, leading to increase cGMP production (PubMed: 14523025, PubMed: 17951249). Required to enhance physical endurance: induced following physical exercise in muscle and promotes cGMP production, probably by interacting with NPR3/NPR-C (PubMed: 26668395). May act as an autocrine and paracrine factor linked to glucose metabolism in skeletal muscle (PubMed: 15044443).
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