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Background
Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP (PubMed: 18450470, PubMed: 17675517, PubMed: 29045903). Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8 (By similarity). Possibly involved in helper T-cell function. [Isoform B]: Inhibits IL-33 signaling.
