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Background
Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on ‘Ser-15’.
Product overview
Product Name
Protein Phosphatase 1 Regulatory Subunit 15A
Code
E6924Hu
Assay type
Sandwich
Size
96 test
Sensitivity
10.69ng/L
Reactivity
Human
Detection range
10.69ng/L
Sample type
Serum, plasma, cell culture supernates
Synonyms
Growth arrest and DNA damage-inducible protein GADD34;Myeloid differentiation primary response protein MyD116 homolog;PPP1R15A;Protein phosphatase 1 regulatory subunit 15A
